USA Functional Medicine MDs, DOs, NDs, DCs and Nutrition Professionals surveyed in 2025 for Designs for Health.HTN Supreme™ contains nutrients that address various machanisms in order to help promote healthy blood pressure. Bonito Peptides and Grape Seed Extract (Vitis vinefera) are included for their anitoxidant activity, cardioprotective properties, and promotion of normal vascular tone.